Proven Shake Flask Equivalent Data using the SPA™ Method

SPA™ Solubility Assay Service

The SPA™ Method assists early-stage decision-making by providing crucial, and previously unattainable, information about substances in development.

Combining low sample consumption with speed and accuracy, the SPA™ Method offers a completely new way to address the central challenges of drug development: expense and duration.

Minuscule sample size <100ug

Chemistry Agnostic

Make Decisions Earlier

No need for Accurate Weight

Download Our Free Whitepapers

All FREE Whitepapers are available to download today:

SPA™ Technology Whitepaper

Chemistry Agnostic Whitepaper

UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper

SPA™ Assisted Modelling Whitepaper.

Why SPA™ Solubility Assay?

Shake Flask Equivalent Data
Measured in less than 60 minutes, in temperatures from 5 to 80 C 

Assays in:

  • USP buffers 
  • Custom Aqueous Buffer ranging from pH 1 to pH 14
  •  Process/Organic Solvents
  • Lipids/Oils 
  • Formulation Vehicles
  • Solvent Mixtures 

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Thank you for your interest in The Solubility Company.


Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.

Other Services

SPA™ Developability Profile

The development route of an API  and pKa from solubility profile, using the SPA™ Method

SPA™ Dissolution Rate Assay


SPA™ Dissolution Rate is measured from less than 100 μg of solid sample



Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous