Proven Shake Flask Equivalent using the SPA™ Method

SPA™ Solubility Assay Service

The SPA™ Method assists early-stage decision-making by providing crucial, and previously unattainable, information about substances in development.

Combining low sample consumption with speed and accuracy, the SPA™ Method offers a completely new way to address the central challenges of drug development: expense and duration.

Minuscule sample size <100ug

Chemistry Agnostic

Make Decisions Earlier

No need for Accurate Weight

Download Our Free Whitepapers

All FREE Whitepapers are available to download today:

SPA™ Technology Whitepaper

Chemistry Agnostic Whitepaper

UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper

SPA™ Assisted Modelling Whitepaper.

Why SPA™ Solubility Assay?

Shake Flask Equivalent Data
Measured in less than 60 minutes, in the following types of buffers and solvents, in temperatures from 5 C – 80 C 

Assays in:

USP buffers ranging from pH 1 up to pH 14

Custom Aqueous Buffer

 Biorelevant buffers including, FaSSGF, FeSSIF and FaSSIF

Simulated and Biological Fluids

Process/Organic Solvents

Lipids 

Formulation Vehicles

Solvent Mixtures 

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Results

Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.

Other Services

SPA™ Developability Profile

The development route of an API  and pKa from solubility profile, using the SPA™ Method

SPA™ Dissolution Rate Assay

NEW! 

SPA™ Dissolution Rate is measured from less than 100 μg of solid sample

PLM

NEW! 

Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous