{"id":2335,"date":"2024-02-05T17:33:16","date_gmt":"2024-02-05T17:33:16","guid":{"rendered":"https:\/\/www.thesolubilitycompany.com\/?page_id=2335"},"modified":"2024-03-01T12:35:01","modified_gmt":"2024-03-01T12:35:01","slug":"dsc_tsc","status":"publish","type":"page","link":"https:\/\/www.thesolubilitycompany.com\/dsc_tsc\/","title":{"rendered":"Differential Scanning Calorimetry"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2335\" class=\"elementor elementor-2335\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32c2d64 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32c2d64\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-33eb00b\" data-id=\"33eb00b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e3e3997 elementor-widget elementor-widget-heading\" data-id=\"1e3e3997\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-large\">DSC Analysis for Solid State Characterization <\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b7f56c3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b7f56c3\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-49ed02b\" data-id=\"49ed02b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12925e6 elementor-widget elementor-widget-image\" data-id=\"12925e6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"240\" height=\"240\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2023\/11\/Mettler_DSC3.png\" class=\"attachment-large size-large wp-image-2379\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2023\/11\/Mettler_DSC3.png 240w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2023\/11\/Mettler_DSC3-150x150.png 150w\" sizes=\"(max-width: 240px) 100vw, 240px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c07cc5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c07cc5b\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70995a32\" data-id=\"70995a32\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a650939 elementor-widget elementor-widget-menu-anchor\" data-id=\"7a650939\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\nbody.elementor-page .elementor-widget-menu-anchor{margin-bottom:0}<\/style>\t\t<div id=\"story\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3f2964ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f2964ae\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-49be2279\" data-id=\"49be2279\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a4974d elementor-widget elementor-widget-text-editor\" data-id=\"25a4974d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><strong>Differential Scanning Calorimetry\u00a0<\/strong>is a key analytical method that measures heat changes in a material as a function of temperature. It is particularly useful for small molecule characterization, offering insights into:<\/p><ul><li>Melting behaviors<\/li><li>Phase transitions<\/li><li>Polymorphism<\/li><li>Thermal stability<\/li><li>Crystallinity<\/li><\/ul><div>\u00a0<\/div><p><strong>DSC Process Overview<\/strong><\/p><ul><li><strong>Sample Preparation:<\/strong> Accurate weighing and sealing of the sample in a specialized pan.<\/li><li><strong>Temperature Control:<\/strong> Application of a precise temperature program, including heating and cooling.<\/li><li><strong>Heat Flow Analysis:<\/strong> Measurement of heat flow differences between the sample and a reference.<\/li><li><strong>Data Interpretation:<\/strong> Extraction of thermal properties such as transition temperatures and enthalpies from the thermogram.<\/li><\/ul><div>\u00a0<\/div><p><strong>Applications of DSC in Solid State Characterization<\/strong><\/p><ul><li><strong>Polymorphism Identification:<\/strong> Analyzing different crystalline forms affecting bioavailability and stability.<\/li><li><strong>Crystallinity Assessment:<\/strong> Determining crystalline vs. amorphous content, influencing dissolution rates and stability.<\/li><li><strong>Melting and Decomposition Analysis:<\/strong> Establishing critical temperatures for formulation and storage.<\/li><li><strong>Glass Transition Detection:<\/strong> Identifying amorphous regions in the sample.<\/li><\/ul><p><strong>Why Choose The Solubility Company for DSC Analysis?<\/strong><\/p><ul><li><strong>State-of-the-Art Equipment:<\/strong> Utilization of the latest DSC technology for precise and reliable results.<\/li><li><strong>Professional Expertise:<\/strong> Our team offers specialized knowledge in solid-state science and small molecule characterization.<\/li><li><strong>Customized Services:<\/strong> Tailored studies to suit various needs, including research, quality control, and regulatory compliance.<\/li><li><strong>Comprehensive Data Reporting:<\/strong> In-depth analysis and detailed reporting for actionable insights.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f63d6fd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f63d6fd\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7b0091d\" data-id=\"7b0091d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43a3b6a3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43a3b6a3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25e927c\" data-id=\"25e927c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a1868f6 elementor-widget elementor-widget-heading\" data-id=\"7a1868f6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Types of Studies<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af70e55 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af70e55\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-ac736c6\" data-id=\"ac736c6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cda8279 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"cda8279\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-image-box .elementor-image-box-content{width:100%}@media (min-width:768px){.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper,.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{display:flex}.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{text-align:right;flex-direction:row-reverse}.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper{text-align:left;flex-direction:row}.elementor-widget-image-box.elementor-position-top .elementor-image-box-img{margin:auto}.elementor-widget-image-box.elementor-vertical-align-top .elementor-image-box-wrapper{align-items:flex-start}.elementor-widget-image-box.elementor-vertical-align-middle .elementor-image-box-wrapper{align-items:center}.elementor-widget-image-box.elementor-vertical-align-bottom .elementor-image-box-wrapper{align-items:flex-end}}@media (max-width:767px){.elementor-widget-image-box .elementor-image-box-img{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-image-box .elementor-image-box-img{display:inline-block}.elementor-widget-image-box .elementor-image-box-title a{color:inherit}.elementor-widget-image-box .elementor-image-box-wrapper{text-align:center}.elementor-widget-image-box .elementor-image-box-description{margin:0}<\/style><div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B.png\" class=\"attachment-full size-full wp-image-265\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B.png 512w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B-300x300.png 300w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B-150x150.png 150w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Polymorphism Identification<\/h3><p class=\"elementor-image-box-description\">Analyzing different crystalline forms affecting bioavailability and stability.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-63ffe60\" data-id=\"63ffe60\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd2272c elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"cd2272c\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b.png\" class=\"attachment-full size-full wp-image-267\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b.png 512w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b-300x300.png 300w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b-150x150.png 150w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Crystallinity Assessment<\/h3><p class=\"elementor-image-box-description\">Determining crystalline vs. amorphous content, influencing dissolution rates and stability.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0bd7134\" data-id=\"0bd7134\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45a4690 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"45a4690\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"592\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1.png\" class=\"attachment-full size-full wp-image-268\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1.png 592w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1-300x259.png 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Melting and Decomposition Analysis<\/h3><p class=\"elementor-image-box-description\">Establishing critical temperatures for formulation and storage.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b3964c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b3964c5\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-be9b407\" data-id=\"be9b407\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>DSC Analysis for Solid State Characterization Differential Scanning Calorimetry\u00a0is a key analytical method that measures heat changes in a material as a function of temperature. It is particularly useful for small molecule characterization, offering insights into: Melting behaviors Phase transitions Polymorphism Thermal stability Crystallinity \u00a0 DSC Process Overview Sample Preparation: Accurate weighing and sealing of [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Differential Scanning Calorimetry - The Solubility Company<\/title>\n<meta name=\"description\" content=\"Elevate your research with our precise Differential Scanning Calorimetry services. 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