{"id":2440,"date":"2024-02-05T17:38:05","date_gmt":"2024-02-05T17:38:05","guid":{"rendered":"https:\/\/www.thesolubilitycompany.com\/?page_id=2440"},"modified":"2024-03-01T14:16:47","modified_gmt":"2024-03-01T14:16:47","slug":"plm_tsc","status":"publish","type":"page","link":"https:\/\/www.thesolubilitycompany.com\/plm_tsc\/","title":{"rendered":"Polarised Light Microscopy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2440\" class=\"elementor elementor-2440\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32c2d64 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32c2d64\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-33eb00b\" data-id=\"33eb00b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e3e3997 elementor-widget elementor-widget-heading\" data-id=\"1e3e3997\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-large\">Polarized Light Microscopy (PLM) Analysis for Drug Powder Characterization\n<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d4b2e76 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d4b2e76\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c573f79\" data-id=\"c573f79\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ac5cfd elementor-widget elementor-widget-image\" data-id=\"1ac5cfd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"160\" height=\"262\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2023\/11\/Nikon_PLM.png\" class=\"attachment-large size-large wp-image-2405\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c07cc5b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c07cc5b\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70995a32\" data-id=\"70995a32\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a650939 elementor-widget elementor-widget-menu-anchor\" data-id=\"7a650939\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\nbody.elementor-page .elementor-widget-menu-anchor{margin-bottom:0}<\/style>\t\t<div id=\"story\" class=\"elementor-menu-anchor\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3f2964ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3f2964ae\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-49be2279\" data-id=\"49be2279\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a4974d elementor-widget elementor-widget-text-editor\" data-id=\"25a4974d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Polarized Light Microscopy (PLM) is a critical analytical tool in the characterization of drug powders, vital for understanding their microstructural properties and behavior. PLM is particularly adept at providing insights into:<\/p><ul><li>Particle Morphology<\/li><li>Crystallinity and Polymorphism<\/li><li>Flow Properties<\/li><li>Blend Uniformity<\/li><li>Contaminant Detection<\/li><\/ul><div>\u00a0<\/div><p><strong>PLM Process for Drug Powder Analysis<\/strong><\/p><ul><li><strong>Sample Preparation:<\/strong> Careful preparation of drug powder samples to ensure representative and homogenous analysis.<\/li><li><strong>Polarization Techniques:<\/strong> Employing polarized light to enhance the visualization of powder particles&#8217; microscopic features.<\/li><li><strong>Microstructural Examination: Detailed<\/strong> observation of the powder&#8217;s physical characteristics, such as shape, size, and arrangement.<\/li><li><strong>High-Quality Imaging:<\/strong> Capturing precise images for thorough analysis of powder quality and consistency.<\/li><\/ul><div>\u00a0<\/div><p><strong>Applications of PLM in Drug Powder Analysis<\/strong><\/p><ul><li><strong>Morphological Assessment: <\/strong>Analyzing the shape and size of drug powder particles, impacting dissolution rates and bioavailability.<\/li><li><strong>Polymorph Identification:<\/strong> Differentiating between various crystalline forms of a drug, essential for efficacy and stability.<\/li><li><strong>Powder Flow Characterization:<\/strong> Studying the powder&#8217;s physical properties to optimize manufacturing and processing.<\/li><li><strong>Quality Assurance:<\/strong> Inspecting drug powders for uniformity, purity, and the presence of any foreign particles.<\/li><\/ul><div>\u00a0<\/div><p><strong>Why Choose The S<\/strong><strong>olubility Company <\/strong><strong>for PLM Analysis?<\/strong><\/p><ul><li><strong>State-of-the-Art Equipment:<\/strong> Utilization of the latest PLM technology for precise and reliable results.<\/li><li><strong>Professional Expertise:<\/strong> Our team offers specialized knowledge in solid-state science and small molecule characterization.<\/li><li><strong>Customized Services:<\/strong> Tailored studies to suit various needs, including research, quality control, and regulatory compliance.<\/li><li><strong>Comprehensive Data Reporting:<\/strong> In-depth analysis and detailed reporting for actionable insights.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43a3b6a3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43a3b6a3\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25e927c\" data-id=\"25e927c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a1868f6 elementor-widget elementor-widget-heading\" data-id=\"7a1868f6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Types of Studies<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af70e55 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af70e55\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-ac736c6\" data-id=\"ac736c6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cda8279 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"cda8279\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.18.0 - 20-12-2023 *\/\n.elementor-widget-image-box .elementor-image-box-content{width:100%}@media (min-width:768px){.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper,.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{display:flex}.elementor-widget-image-box.elementor-position-right .elementor-image-box-wrapper{text-align:right;flex-direction:row-reverse}.elementor-widget-image-box.elementor-position-left .elementor-image-box-wrapper{text-align:left;flex-direction:row}.elementor-widget-image-box.elementor-position-top .elementor-image-box-img{margin:auto}.elementor-widget-image-box.elementor-vertical-align-top .elementor-image-box-wrapper{align-items:flex-start}.elementor-widget-image-box.elementor-vertical-align-middle .elementor-image-box-wrapper{align-items:center}.elementor-widget-image-box.elementor-vertical-align-bottom .elementor-image-box-wrapper{align-items:flex-end}}@media (max-width:767px){.elementor-widget-image-box .elementor-image-box-img{margin-left:auto!important;margin-right:auto!important;margin-bottom:15px}}.elementor-widget-image-box .elementor-image-box-img{display:inline-block}.elementor-widget-image-box .elementor-image-box-title a{color:inherit}.elementor-widget-image-box .elementor-image-box-wrapper{text-align:center}.elementor-widget-image-box .elementor-image-box-description{margin:0}<\/style><div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B.png\" class=\"attachment-full size-full wp-image-265\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B.png 512w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B-300x300.png 300w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/microscope_B-150x150.png 150w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Crystallinity Identification <\/h3><p class=\"elementor-image-box-description\">Determining the crystallinity of each sample.  Differentiate between crystalline, amorphous and partial crystalline samples.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-63ffe60\" data-id=\"63ffe60\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd2272c elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"cd2272c\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b.png\" class=\"attachment-full size-full wp-image-267\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b.png 512w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b-300x300.png 300w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/productivity_b-150x150.png 150w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Morphological Assessment <\/h3><p class=\"elementor-image-box-description\">Analysing the shape and size of drug powder particles to estimate the impact on developability. <\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0bd7134\" data-id=\"0bd7134\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45a4690 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"45a4690\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"592\" height=\"512\" src=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1.png\" class=\"attachment-full size-full wp-image-268\" alt=\"\" srcset=\"https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1.png 592w, https:\/\/www.thesolubilitycompany.com\/wp-content\/uploads\/2020\/10\/cancel-1-300x259.png 300w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Sample Uniformity<\/h3><p class=\"elementor-image-box-description\">Determine if samples are uniform or a mixture of different crystal species. <\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b3964c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b3964c5\" data-element_type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-be9b407\" data-id=\"be9b407\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Polarized Light Microscopy (PLM) Analysis for Drug Powder Characterization Polarized Light Microscopy (PLM) is a critical analytical tool in the characterization of drug powders, vital for understanding their microstructural properties and behavior. PLM is particularly adept at providing insights into: Particle Morphology Crystallinity and Polymorphism Flow Properties Blend Uniformity Contaminant Detection \u00a0 PLM Process for [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Polarised Light Microscopy - The Solubility Company<\/title>\n<meta name=\"description\" content=\"Explore our PLM analysis services that can offer expert insights into drug powder characteristics such as particle morphology, crystallinity, and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.thesolubilitycompany.com\/plm_tsc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Polarised Light Microscopy - 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