Developability Profile and pKa from solubility profile using the SPA™ Method

SPA™ Developability Profile Service

Early determination of the actual solubility and pKa values is essential in drug discovery to understand the absorption behaviour of an API and to drive the formulation of the product.  Choose the best development route for your API with less then 1mg of sample, using the SPA™ Method.

Single or Multiple pKas

Real Data for Insilico Models

Solubility and Developability Information

<1 mg Sample Needed

Download Our Free Whitepapers

All FREE Whitepapers are available to download today:

SPA™ Technology Whitepaper

Chemistry Agnostic Whitepaper

UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper

SPA™ Assisted Modelling Whitepaper.

Why SPA™ Developability Profile?

Solubility and pKa Combined!
Thanks to the unique way the SPA Assay works, less than 1mg of sample will give 10 solubility data points and the pKa profile of your sample.   

pKa information is generated alongside SPA Solubility Data, a powerful insight into the developability of your sample.  

Buffers used
• USP or custom buffers ranging from pH 1.0 up to pH 14.0

Contact Us

Please enter your name and email address below, and we’ll get back to you as soon as possible. 

Thank you for your interest in The Solubility Company.


Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.

Other Services

SPA™ Solubility Assay

SPA™ solubility is measured from less than 100 μg of solid sample

SPA™ Dissolution Rate Assay


SPA™ Dissolution Rate is measured from less than 100 μg of solid sample



Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous