The development route of an API and pKa from solubility profile, using the SPA™ Method with <1mg of material. Early determination of the actual pKa values is essential in drug discovery to understand the absorption behaviour of an API and to drive the formulation of the product.
All FREE Whitepapers are available to download today:
SPA™ Technology Whitepaper
Chemistry Agnostic Whitepaper
UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper
SPA™ Assisted Modelling Whitepaper.
Shake flask data and pKa Combined!
Due to the unique way the SPA Assay works for less than 1mg of the sample you can have 10 solubility data points and the pKa profile of your sample.
pKa information is generated alongside SPA Solubility Data, a powerful insight into the developability of our sample.
Using the SPA method
• 10 minutes run
• Constant flow
• USP buffers ranging from pH 1.0 up to pH 12.0
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Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.
SPA™ solubility is measured from less than 100 μg of solid sample
SPA™ Dissolution Rate is measured from less than 100 μg of solid sample
Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous