Developability Profile and pKa from solubility profile using the SPA™ Method

SPA™ Developability Profile Service

The development route of an API  and pKa from solubility profile, using the SPA™ Method with <1mg of material. Early determination of the actual pKa values is essential in drug discovery to understand the absorption behaviour of an API and to drive the formulation of the product.

Single or Multiple pKas

Real Data for Insilico Models

Solubility and Developability Information

<1 mg Sample Needed

Download Our Free Whitepapers

All FREE Whitepapers are available to download today:

SPA™ Technology Whitepaper

Chemistry Agnostic Whitepaper

UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper

SPA™ Assisted Modelling Whitepaper.

Why SPA™ Developability Profile?

Shake flask data and pKa Combined!
Due to the unique way the SPA Assay works for less than 1mg of the sample you can have 10 solubility data points and the pKa profile of your sample.   

pKa information is generated alongside SPA Solubility Data, a powerful insight into the developability of our sample.  

Using the SPA method
• 10 minutes run
• Constant flow

Buffers used
• USP buffers ranging from pH 1.0 up to pH 12.0

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Thank you for your interest in The Solubility Company.


Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.

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