Dissolution Rate or Intrinsic Dissolution Rate (IDR) is a measure of the rate of dissolution of a pure sample where the conditions of surface area, temperature, agitation/stirring speed, medium pH, and ionic strength are all kept
constant. IDR is important during the development of new drug molecules as it is possible to predict potential problems using very small quantities of material. It has applications in evaluating drug solubility in accordance with the biopharmaceutics classification system (BCS), comparison of the dissolution rate during salt selection or polymorph screening to choose the best candidate, and setting specifications for particle size in order to achieve complete dissolution of the required dose within the typical gastrointestinal transfer time. IDR screening can be applied to promising drug candidates to guide early development efforts to improve a drug’s in vivo characteristics.
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SPA™ Technology Whitepaper
Chemistry Agnostic Whitepaper
UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper
SPA™ Assisted Modelling Whitepaper.
Quickest, Earlier IDR Data Ever!
The accuracy of models fed with real experimental data increases considerably.
IDR data for generated alongside SPA Solubility Data, a powerful tool for Polymorph screens.
Using the SPA method
Short Assay Time
The surface area determined for each sample
USP buffers ranging from pH 1.0 up to pH 12.0
Biorelevant buffers: FaSSGF, FeSSIF, FaSSIF
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Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.
SPA™ solubility is measured from less than 100 μg of solid sample
The development route of an API and pKa from solubility profile, using the SPA™ Method
Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous