Dissolution Rate and Intrinsic Dissolution using the SPA™ Method

SPA™ Dissolution Rate Assay Service

Dissolution Rate is critical for the development of new drug modalities. The SPA™ Method measures the rate of dissolution of a pure sample when all important parameters are known (surface area, temperature, agitation/stirring speed, medium pH, and ionic strength). With <100ug of sample you can measure rather than predict downstream issues. The SPA™ Method gives earlier information to help select for example the most optimal polymorph or salt to move forward with in development.

Dissolution Rate Earlier

<1mg of API for Dissolution Assays

Data During Polymorph Screen

Actual Microscale Dissolution

Download Our Free Whitepapers

All FREE Whitepapers are available to download today:

SPA™ Technology Whitepaper

Chemistry Agnostic Whitepaper

UPDATED! Comparison SPA™ Assay vs Shake Flask Whitepaper

SPA™ Assisted Modelling Whitepaper.

Why SPA™ Dissolution Rate?

Quickest, Earliest IDR Data Ever!
Increase the accuracy of your models with accurate experimental data. 

IDR data generated alongside SPA Solubility Data, as a powerful tool for Polymorph screens.   

Using the SPA method
Short Assay Time

The surface area determined for each particle

Less than 100ug of sample

Buffers used
USP or custom buffers ranging from pH 1.0 up to pH 14.0

Process solvents 

Biorelevant buffers: FaSSGF, FeSSIF, FaSSIF

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Results are fully reported to the client normally within 10 days of the sample arriving in Helsinki, faster turnarounds are available for time-critical projects.

Other Services

SPA™ Solubility Assay

SPA™ solubility is measured from less than 100 μg of solid sample

SPA™ Developability Profile

The development route of an API  and pKa from solubility profile, using the SPA™ Method



Polarized Light Microscopy Service, determine if your sample is crystaline or amorphous