Research smarter,
Deliver faster.

Small-scale

Sample amounts of less than 100 µg per measurement.

Reliable & Fast

'Gold standard' comparable results obtained in less than an hour.

Safe

Measurements do not require knowledge of chemical structure.

- Optimized for early-stage development

 

The SPA™ Method

Single Particle Analysis (SPA),

image-based rapid and reliable solubility screening.

Minuscule sample size <100 µg

High content imaging

Intelligent algorithms & analysis

The SPA™ Method assists early-stage decision-making by providing crucial, and previously unattainable, information about substances in development. Combining low sample consumption with speed and accuracy, the SPA™ Method offers a completely new way to address the central challenges of drug development: expense and duration.

The single particle analysis, SPA™ Method is the world’s first method for rapidly and accurately measuring solubility from very small amounts of solid substance. Through the innovative combination of optics, fluidics, machine vision and intelligent algorithms, the SPA™ Method measures the solubility and related physicochemical parameters of practically any solid sample in practically any transparent solvent.

logD
logP
Intrinsic solubility
Organic solubility
Equilibrium / apparent solubility
Bio- relevant solubility
Native solubility
pKa
 
 

SPA™ Method Benefits

Kinetic solubility

µg amounts / assay

Rapid

Inaccurate

The SPA™ Method

µg amounts / assay

Rapid

Accurate

Equilibrium solubility

mg amounts / assay

Slow

Accurate

 

Services

We offer a range of physicochemical measurement services based on the proprietary SPA™ method:​

in buffer solutions, physiological solutions and organic solvents.

Solubility

SPA™ solubility is measured from less than 100 μg of solid sample

pKa
 

From less than 1 mg of solid sample one or multiple pKa:s of the sample are approximated based on the pH-dependent solubility profile

 
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