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THE SOLUBILITY COMPANY

Viikinkaari 4

00790 Helsinki

FINLAND

EVENTS

© 2019 by The Solubility Company Ltd.

Image-based rapid and reliable solubility screening

Small-scale

Optimized for early-stage development.

Sample amounts of less than 100 µg per measurement.

Reliable & Fast

'Gold standard' comparable results obtained within one hour per sample.

Safe

Measurements do not require knowledge of chemical structure.

The Solubility Company is a preclinical contract research organization (CRO) providing solubility measurement services based on the proprietary image-based SPA method.

Our service laboratory is based in Helsinki, Finland and is operated by a highly skilled team with more than 50 years of experience in pharmaceutical development, high-tech R&D and management.

 

The SPA Method

Single Particle Analysis (SPA),

image-based rapid and reliable solubility screening.

logD
pKa
logP
Intrinsic solubility
Organic solubility
Native solubility
Equilibrium/ apparent solubility
Biorelevant solubility

The SPA Method assists early-stage decision-making by providing crucial, and previously unattainable, information about substances in development. Combining low sample consumption with speed and accuracy, the SPA Method offers a completely new way to address the central challenges of drug development: expense and duration.

The single particle analysis, SPA Method is the world’s first method for rapidly and accurately measuring solubility from very small amounts of solid substance. Through the innovative combination of optics, fluidics, machine vision and intelligent algorithms, the SPA Method measures the solubility and related physicochemical parameters of practically any solid sample in practically any transparent solvent.

<100µg

We claim: Using the SPA –method it is possible to determine the solubility and other related physicochemical parameters of compounds from individual samples of less than 100 μg.

 

Services

We offer a range of physicochemical measurement services based on the proprietary SPA method:

  • thermodynamic/apparent/intrinsic/native solubility

  • dissolution rate

  • pKa

  • logP and logD

in buffer solutions, physiological solutions and organic solvents.

 

Who we are

The Solubility Company is a preclinical contract research organization (CRO) providing solubility measurement services based on the proprietary image-based SPA method.

Our service laboratory is based in Helsinki, Finland and is operated by a highly skilled team with more than 50 years of experience in pharmaceutical development, high-tech R&D and management.