Polarized Light Microscopy (PLM) Analysis for Drug Powder Characterization

Polarized Light Microscopy (PLM) is a critical analytical tool in the characterization of drug powders, vital for understanding their microstructural properties and behavior. PLM is particularly adept at providing insights into:

  • Particle Morphology
  • Crystallinity and Polymorphism
  • Flow Properties
  • Blend Uniformity
  • Contaminant Detection

PLM Process for Drug Powder Analysis

  • Sample Preparation: Careful preparation of drug powder samples to ensure representative and homogenous analysis.
  • Polarization Techniques: Employing polarized light to enhance the visualization of powder particles’ microscopic features.
  • Microstructural Examination: Detailed observation of the powder’s physical characteristics, such as shape, size, and arrangement.
  • High-Quality Imaging: Capturing precise images for thorough analysis of powder quality and consistency.

Applications of PLM in Drug Powder Analysis

  • Morphological Assessment: Analyzing the shape and size of drug powder particles, impacting dissolution rates and bioavailability.
  • Polymorph Identification: Differentiating between various crystalline forms of a drug, essential for efficacy and stability.
  • Powder Flow Characterization: Studying the powder’s physical properties to optimize manufacturing and processing.
  • Quality Assurance: Inspecting drug powders for uniformity, purity, and the presence of any foreign particles.

Why Choose The Solubility Company for PLM Analysis?

  • State-of-the-Art Equipment: Utilization of the latest PLM technology for precise and reliable results.
  • Professional Expertise: Our team offers specialized knowledge in solid-state science and small molecule characterization.
  • Customized Services: Tailored studies to suit various needs, including research, quality control, and regulatory compliance.
  • Comprehensive Data Reporting: In-depth analysis and detailed reporting for actionable insights.

Types of Studies

Crystallinity Identification

Determining the crystallinity of each sample. Differentiate between crystalline, amorphous and partial crystalline samples.

Morphological Assessment

Analysing the shape and size of drug powder particles to estimate the impact on developability.

Sample Uniformity

Determine if samples are uniform or a mixture of different crystal species.