DSC Analysis for Solid State Characterization

Differential Scanning Calorimetry is a key analytical method that measures heat changes in a material as a function of temperature. It is particularly useful for small molecule characterization, offering insights into:

• Melting behaviors
• Phase transitions
• Polymorphism
• Thermal stability
• Crystallinity

DSC Process Overview

• Sample Preparation: Accurate weighing and sealing of the sample in a specialized pan.
• Temperature Control: Application of a precise temperature program, including heating and cooling.
• Heat Flow Analysis: Measurement of heat flow differences between the sample and a reference.
• Data Interpretation: Extraction of thermal properties such as transition temperatures and enthalpies from the thermogram.

Applications of DSC in Solid State Characterization

• Polymorphism Identification: Analyzing different crystalline forms affecting bioavailability and stability.
• Crystallinity Assessment: Determining crystalline vs. amorphous content, influencing dissolution rates and stability.
• Melting and Decomposition Analysis: Establishing critical temperatures for formulation and storage.
• Glass Transition Detection: Identifying amorphous regions in the sample.

Why Choose The Solubility Company for DSC Analysis?

• State-of-the-Art Equipment: Utilization of the latest DSC technology for precise and reliable results.
• Professional Expertise: Our team offers specialized knowledge in solid-state science and small molecule characterization.
• Customized Services: Tailored studies to suit various needs, including research, quality control, and regulatory compliance.
• Comprehensive Data Reporting: In-depth analysis and detailed reporting for actionable insights.