X-Ray Powder Diffraction Analysis (XRPD) for Crystallographic Characterization

Powder XRD Instrument

What is X-Ray powder diffraction ( XRPD) Analysis and why is it important?

X-Ray Powder Diffraction (XRPD) is a powerful technique used for the analysis of crystalline materials. It provides essential data on crystal structure, phase identification, and purity. 

What is XRPD Analysis used for?

XRPD Analysis Is Crucial For:

  • Phase Identification

  • Crystal Structure Analysis

  • Particle Size Estimation

  • Quantitative Phase Analysis

  • Lattice Parameter Measurements

XRPD xray powder diffraction graph

Our XRPD Services
In Material Science

Phase Identification:

Determining the presence of different crystalline phases in a sample, essential for understanding material properties.

Particle Size Analysis:

Estimating the size of crystalline regions, impacting dissolution rates and mechanical properties

X-Ray Crystallography:

Elucidating the crystal structure of materials for insight into physical properties involves analyzing the diffraction peaks obtained from XRD. chemical properties

Purity Analysis:

Assessing the purity of materials by identifying and quantifying phases.

Our Powder X-Ray diffraction (XRPD) Analysis Process

1

Sample Preparation:

Essential for obtaining accurate X-ray diffraction patterns. Proper grinding and mounting of the sample to ensure a representative and random orientation of crystals.

2

X-Ray Diffraction:

Bombardment of the sample with X-rays and detection of diffracted beams.

3

Pattern Acquisition:

Collection of diffraction patterns as a function of the angle of incidence

4

Data Analysis:

Interpretation of diffraction patterns to determine crystal structure, phase content, and other properties.

Advantages of Our Services for XRPD Pharmaceutical Analysis

  1. State-of-the-Art Equipment: Utilization of the latest XRPD technology for precise and reliable results.

  2. Professional Expertise: Our team offers specialized knowledge in solid-state science and small molecule characterization.

  3. Customized Services: Tailored studies to suit various needs, including research, quality control, and regulatory compliance.

  4. Comprehensive Data Reporting: In-depth analysis and detailed reporting for actionable insights.

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Frequently Asked Questions

XRD (X-ray diffraction) is a technique for studying the crystalline structure of materials, which can be used on single crystals or polycrystalline sample. Powder XRD (PXRD) is a specific type of XRD used for analyzing powdered or polycrystalline samples, focusing on phase identification and lattice parameters. PXRD is generally faster and simpler, while single crystal XRD provides detailed 3D atomic structures.

XRD is used to determine both qualitative and quantitative aspects of materials. Qualitatively, it identifies phases and crystal structures in a material. Quantitatively, it can determine the amounts of different phases, crystallite sizes, and lattice parameters.

XRD can test a variety of samples, including single crystals, powders, thin films, and polycrystalline materials.

  • Analyze Biominerals: Study the structure of bones, teeth, and other calcified tissues using X-ray diffraction techniques to obtain diffraction data.
  • Pharmaceuticals: Identify and quantify different crystalline forms of drugs using single crystal diffraction to ensure quality and efficacy through x-ray wavelength analysis.
  • Protein Crystallography: Determine the 3D structure of proteins and other biomolecules for drug design and research.
  • Medical Implants: Assess the crystalline structure of materials used in implants to ensure their stability and performance.