Scanning Electron Microscopy

Scanning Electron Microscopy (SEM) Analysis for Small Molecule Pharmaceutical Characterization

SEM Analysis is an essential technique in pharmaceutical research, providing detailed high-resolution images crucial for the characterization of small molecule drugs. This method is instrumental in understanding and controlling drug formulation and manufacturing processes, offering insights into:

• Particle morphology and size distribution
• Crystal habit and polymorphic forms
• Surface defects and impurities
• Drug-carrier interactions in formulations
• Coating integrity in drug delivery systems

SEM Process Overview for Pharmaceutical Analysis

• Sample Preparation: Careful preparation of the pharmaceutical sample, often involving coating with a conductive layer to enhance imaging quality.
• High-Resolution Imaging: Utilizing a focused electron beam to scan the drug particles, achieving nanometer-scale resolution.
• Signal Detection: Collecting secondary and backscattered electrons to generate detailed surface topology images.
• Data Interpretation: Analyzing SEM images to extract critical information about the pharmaceutical sample’s microstructure and surface characteristics.

Applications of SEM in Pharmaceutical Small Molecule Analysis

• Morphology Assessment: Detailed examination of particle shapes and surfaces, essential for understanding dissolution rates and bioavailability.
• Polymorph Characterization: Identifying different crystalline forms of a drug, which can significantly impact its therapeutic efficacy and stability.
• Crystal Imaging: Detailed images of the microstructure and surfaces of crystal, information on effective surface area of the crystal.

Advantages of Choosing Our Services for SEM Pharmaceutical Analysis

• Cutting-Edge SEM Technology: Utilizing advanced SEM instruments capable of capturing detailed images of small molecule drugs.
• Pharmaceutical Expertise: Our team specializes in the analysis of pharmaceuticals, offering deep insights into small molecule characterization.
• Tailored Analytical Approaches: Customized studies designed to meet the specific needs of pharmaceutical research and development.
• Comprehensive and Compliant Reporting: Providing thorough analysis and reports, compliant with pharmaceutical regulatory standards.