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SEM Analysis is an essential technique in pharmaceutical research, providing detailed high-resolution images crucial for the characterization of small molecule drugs. This method is instrumental in understanding and controlling drug formulation and manufacturing processes.
Detailed examination of particle shapes and surfaces, essential for understanding dissolution rates and bioavailability.
Detailed images of the microstructure and surfaces of crystal, information on effective surface area of the crystal.
Identifying different crystalline forms of a drug, which can significantly impact its therapeutic efficacy and stability.
Sample Preparation:
Careful preparation of the pharmaceutical sample, often involving coating with a conductive layer to enhance imaging quality.
High-Resolution Imaging:
Utilizing a focused electron beam to scan the drug particles, achieving nanometer-scale resolution.
Signal Detection:
Collecting secondary and backscattered electrons to generate detailed surface topology images.
Data Interpretation:
Analyzing SEM images to extract critical information about the pharmaceutical sample’s microstructure and surface characteristics.
Cutting-Edge SEM Technology: Utilizing advanced SEM instruments capable of capturing detailed images of small molecule drugs.
Pharmaceutical Expertise: Our team specializes in the analysis of pharmaceuticals, offering deep insights into small molecule characterization.
Tailored Analytical Approaches: Customized studies designed to meet the specific needs of pharmaceutical research and development.
Comprehensive and Compliant Reporting: Providing thorough analysis and reports, compliant with pharmaceutical regulatory standards.
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The main distinction between SEM and TEM lies in how they create images. SEM relies on detecting reflected or dislodged electrons, while TEM utilizes transmitted electrons that pass through the sample to generate images.
When utilizing a scanning electron microscope (SEM), it commonly detects two distinct electron types: backscattered electrons (BSEs) and secondary electrons (SEs).
SEM lets you see compositional differences that optical images miss. When you use benchtop SEM to examine pharmaceutical tablets or powder samples, you’ll notice finer details and compositional differences compared to optical microscopes, even at the same magnification.”
SEM provides a magnification range from approximately 10 to 3,000,000 times, spanning about six orders of magnitude. Unlike optical and transmission electron microscopes, SEM image magnification isn’t reliant on the objective lens power.
Among instrumental methods, the scanning electron microscope (SEM) holds a prominent position for examining and analyzing micro- and nanoparticles alongside characterizing solid objects. SEM’s preference in particle size analysis stems from its remarkable resolution capability, which extends to 10 nm or 100 Å.
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